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Image Search Results
Journal: European Journal of Human Genetics
Article Title: LTBP2 null mutations in an autosomal recessive ocular syndrome with megalocornea, spherophakia, and secondary glaucoma
doi: 10.1038/ejhg.2010.11
Figure Lengend Snippet: Linkage analysis in family 1. The parents were second cousins. The 14q linkage region was initially identified by a genome-wide 10 K GeneChip microarray of SNPs in three affected siblings, then further analyzed by microsatellite polymorphisms in affected and unaffected siblings and parents, as shown. A single linkage region was found where all patients and no unaffected siblings were homozygous, yielding a maximal multipoint LOD score of 2.87 at D14S1002.
Article Snippet: A genome-wide search for homozygosity was performed in the affected siblings of family 1 using an
Techniques: Genome Wide, Microarray